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Vascular Intervention: From Angioplasty to Bioresorbable Vascular Scaffold

Fengyi Du1, Jiangbing Zhou2

  • 1Departments of Neurosurgery and of Biomedical Engineering, Yale University, New Haven, CT, USA.

Advances in Experimental Medicine and Biology
|October 14, 2018
PubMed

Insights

Bioresorbable vascular scaffolds (BVSs) offer a promising alternative to metallic stents for coronary artery disease, potentially avoiding long-term complications. Further research is needed to fully demonstrate their clinical advantages.

Area of Science:

  • Cardiovascular research
  • Biomaterials science
  • Medical device engineering

Background:

  • Coronary artery disease (CAD) is a major global health concern.
  • Metallic stents, while effective, cause long-term arterial issues like inflammation and restenosis.
  • Bioresorbable vascular scaffolds (BVSs) are being developed to overcome these limitations.

Purpose of the Study:

  • To review the historical development of nonsurgical vascular interventions.
  • To discuss the current state of bioresorbable vascular scaffold technology.
  • To identify and propose solutions for existing BVS limitations.

Main Methods:

  • Literature review of nonsurgical vascular intervention evolution.
  • Analysis of current bioresorbable vascular scaffold development.
  • Exploration of potential strategies to address BVS challenges.

Main Results:

  • Metallic stents have limitations including impaired arterial physiology and adverse effects.
  • Bioresorbable vascular scaffolds (BVSs) offer temporary support and are resorbed, potentially improving arterial remodeling.
  • The theoretical benefits of BVSs require further clinical validation.

Conclusions:

  • BVSs represent a promising advancement over metallic stents for CAD treatment.
  • Addressing current BVS limitations is crucial for realizing their full clinical potential.
  • Continued research and development are essential for the successful implementation of BVSs.

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