Harnessing Nanotopography of Electrospun Nanofibrous Nerve Guide Conduits (NGCs) for Neural Tissue Engineering

The anatomical recovery of nerve defects with their neurological functions after an injury caused by diseases or accidents is an important clinical issue. The most efficient surgical technique so far to the nerve defects, which are unrepairable by direct end-to-end suture, can be autograft transplantation. The autograft transplantation, however, has disadvantages including multiple rounds of surgery, a shortage of nerve donor, and function loss at the donor site. Tissue-engineered nerve guide conduits (TENGCs) have emerged as a potential alternative to autologous nerve grafts for nerve regeneration and functional recovery. Various TENGCs researches are being carried out to improve characteristics and enhance functionality such as material selection, biomimetic, topography, and enhancement by the biomolecules additions. Among them, the customizable surface nanotopography of aligned fibrous TENGCs foster neural repair by providing a cell-friendly environment, permissiveness, guidance cues, and directional growth of the cells. Fibrous nerve guide conduits (NGCs) made of longitudinally ordered fibers is a promising candidate for nerve tissue engineering.