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Introduction to Human Genetic Epidemiology.

Bertram K C Chan1

  • 1Epidemiology and Biostatistics, Loma Linda University School of Medicine and Public Health, Sunnyvale, CA, USA.

Advances in Experimental Medicine and Biology
|October 26, 2018
PubMed
Summary
This summary is machine-generated.

Human genetic epidemiology (HGP) integrates medicine, public health, and epidemiology. It must now encompass human genetic diversity, including mutation and polymorphism, for modern genetic medicine.

Keywords:
Applied statistical human geneticsCancer genetics and genomicsChromosomal and genomic bases of diseasesClinical cytogeneticsDevelopmental genetics and birth defectsEpidemiologyGenetic bases for human diseasesGenetic medicineGenome analysisGenomics for medicine and personal healthHuman Genome ProjectHuman geneticsHuman genetics and genetic epidemiologyHuman genomeMedicineMolecular basis of genetic diseasesMutation and polymorphismPrenatal diagnosis and screeningPreventive medicinePublic healthRisk assessment and genetic counselingSocial and ethical issues in genetic medicineStatistical human genetics and statistical genetic epidemiologyThe treatment of genetic diseases

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Area of Science:

  • Genetics
  • Epidemiology
  • Public Health

Background:

  • Human genetic epidemiology (HGP) is a multidisciplinary field.
  • It draws upon knowledge from medicine, preventive medicine, public health, and epidemiology.
  • The field is evolving with advancements in genetic medicine.

Purpose of the Study:

  • To highlight the essential role of human genetic diversity in HGP.
  • To emphasize the inclusion of mutation and polymorphism in HGP.
  • To adapt HGP for the modern era of genetic medicine.

Main Methods:

  • Review of current literature in human genetic epidemiology.
  • Analysis of the intersection between genetic diversity and public health.
  • Integration of concepts of mutation and polymorphism into epidemiological frameworks.

Main Results:

  • HGP requires a comprehensive understanding of human genetic diversity.
  • Mutation and polymorphism are critical components of genetic variation.
  • These factors are essential for understanding disease patterns and developing targeted interventions.

Conclusions:

  • HGP must actively incorporate the study of human genetic diversity, including mutation and polymorphism.
  • This integration is crucial for the advancement of genetic medicine and public health strategies.
  • Future research should focus on the epidemiological implications of genetic variation.