HYPERCALCEMIA DUE TO POLYMETHYLMETHACRYLATE INJECTIONS? (LITERATURE REVIEW AND CASE REPORTS)
A Goldman1, H Staub1, U Wollina1
1Clinica Goldman and Hospital Moinhos de Vento, Porto Alegre; Department of Rheumatology, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil; Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University of Dresden, Germany.
Georgian Medical News
|October 26, 2018
Summary
Polymethylmethacrylate (PMMA) injections may be linked to calcitriol-related hypercalcemia, a condition often seen in granulomatous disorders. Further research is needed to confirm this association between PMMA and elevated calcium levels.
Area of Science:
- Endocrinology
- Toxicology
- Dermatology
Background:
- Hypercalcemia is a frequent clinical finding associated with malignancy, bone disorders, and granulomatous diseases.
- Calcitriol-related hypercalcemia is characteristic of granulomatous conditions.
- Recent interest has focused on potential links between cosmetic fillers like polymethylmethacrylate (PMMA) and granulomatous disease with hypercalcemia.
Observation:
- The authors present two cases of patients experiencing calcitriol-related hypercalcemia.
- Both patients had a history of receiving polymethylmethacrylate (PMMA) injections.
Findings:
- The observed cases suggest a potential association between prior PMMA injections and the development of calcitriol-related hypercalcemia.
- This association, while intriguing, is based on a limited number of cases.
Implications:
- The findings highlight a possible, yet unconfirmed, link between cosmetic filler materials and metabolic bone abnormalities.
- Further longitudinal studies are essential to validate the relationship between PMMA and hypercalcemia.
- This could inform clinical practice regarding patient history and potential complications of aesthetic procedures.
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