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PROLIFERATIVE/STEM CELL INDEX AND PHENOTYPIC CHARACTERISTICS OF PROLIFERATIVE PROCESSES IN ENDOMETRIUM
N Kikalishvili1, R Beriashvili1, T Muzashvili1
1Tbilisi State Medical University, Georgia.
Georgian Medical News
|October 26, 2018
Summary
The study found that the proliferative/stem cell index (PR/ST index) correlates with phenotypic characteristics in endometrial carcinoma but not in hyperplasia or dysplasia. PTEN protein negativity increases with malignancy, peaking in Grade 3 endometrial carcinoma.
Area of Science:
- Gynecologic Pathology
- Oncology
- Cell Biology
Background:
- Endometrial proliferative and stem cell indices are crucial for understanding endometrial tissue behavior.
- Phenotypic characteristics of endometrial lesions are key indicators of disease progression and malignancy.
- The role of PTEN expression in endometrial pathologies requires further elucidation.
Purpose of the Study:
- To investigate the relationship between the endometrial proliferative/stem cell index (PR/ST index) and phenotypic characteristics in various endometrial proliferative processes.
- To analyze the correlation of the PR/ST index with PTEN expression across different grades of endometrial hyperplasia, dysplasia, and carcinoma.
Main Methods:
- Retrospective analysis of 83 histopathology specimens from the Acad. N. Kipshidze Central University Clinic.
- Utilized Hematoxylin-eosin staining and immunohistochemistry for Ki67, CD146, and PTEN markers.
- Calculated the PR/ST index as the ratio of Ki67-positive to CD146-positive cell percentages; evaluated PTEN expression scores.
Main Results:
- The PR/ST index did not correlate with phenotypic characteristics in endometrial hyperplasia and dysplasia.
- A strong, direct correlation was observed between the PR/ST index and phenotypic characteristics in endometrial carcinoma of varying grades.
- PTEN expression heterogeneity peaked in Endometrioid Carcinoma Grade 2, while PTEN negativity increased with malignancy, peaking in Grade 3.
Conclusions:
- The PR/ST index is a significant indicator of phenotypic changes and malignancy in endometrial carcinoma.
- PTEN expression patterns, particularly negativity, are associated with increasing endometrial cancer progression.
- These findings highlight the potential of the PR/ST index and PTEN expression as biomarkers in endometrial pathology.
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