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Published on: October 24, 2019

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Severe Brief Resolved Unexplained Event in a Newborn Infant in Association with Maternal Sertralin Treatment during

Mirjam Pocivalnik1, Manfred Danda2, Berndt Urlesberger3

  • 1Division of Neonatology, Department of Pediatrics, Medical University of Graz, 8036 Graz, Austria. mirjampocivalnik@hotmail.com.

Medicines (Basel, Switzerland)
|October 27, 2018
PubMed

Background: Selective serotonin reuptake inhibitors are a very common choice of antidepressive drug-therapy during pregnancy. In up to 30% of cases, they have been found to cause neonatal abstinence syndrome in newborn infants. Although often both time-limiting and self-limiting, severe symptoms of neonatal abstinence syndrome (NAS) can occur. Methods/Results: We report a term male infant suffering from a severe brief resolved unexplained event caused by his mother's sertraline intake during pregnancy. Conclusions: Newborn infants exposed to selective serotonine reuptake inhibitors (SSRIs) during pregnancy should be evaluated very carefully concerning NAS and monitored for NAS symptoms for a minimum of 72⁻96 h, or until symptoms have fully recovered using standardized protocols. There is a risk of severe NAS symptoms which might occur, and this circumstance should be discussed with the parents and taken into account before administering the drug.

Keywords:
apparent life-threatening eventsbrief resolved unexplained eventsneonatal abstinence syndromeselective serotonine reuptake inhibitor

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