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Platelet-Based Drug Delivery for Cancer Applications
Nerymar Ortiz-Otero1, Zeinab Mohamed2, Michael R King3
1Department of Biomedical Engineering, Vanderbilt~University, Nashville, TN, USA.
Advances in Experimental Medicine and Biology
|October 29, 2018
Summary
Platelets, crucial for hemostasis, can also drive cancer metastasis. This chapter explores how platelets facilitate tumor spread and discusses novel therapies targeting platelet interactions in cancer progression.
Area of Science:
- Oncology
- Hematology
- Cell Biology
Background:
- Platelets are essential for hemostasis and vascular integrity.
- Pathological conditions can alter platelet function, promoting disease progression.
- The historical link between platelets and cancer metastasis, known as Trousseau's Syndrome, has been studied since 1865.
Purpose of the Study:
- To elucidate the role of platelets in facilitating cancer metastasis.
- To explore novel cancer therapies targeting platelet interactions.
- To discuss the contribution of platelets in tumor cell transit to distant sites.
Main Methods:
- Review of experimental evidence on platelet function in cancer.
- Analysis of platelet-cancer metastasis relationship.
- Discussion of therapeutic strategies targeting platelet-cancer interactions.
Main Results:
- Platelets play a significant role in promoting tumor cell transit and metastasis.
- Understanding platelet involvement opens avenues for targeted cancer therapies.
- Trousseau's Syndrome highlights the complex interplay between hemostasis and cancer.
Conclusions:
- Platelets are key players in cancer metastasis, not just hemostasis.
- Targeting platelet functions offers promising strategies for novel cancer treatments.
- Further research into platelet-cancer interactions is crucial for therapeutic development.
Keywords:
AbciximabAnticoagulantArtificial plateletCancer metastasisFibrinogenMicrothrombus cloakPlateletTissue factorVon willebrand factorMore Related Videos
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