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Accelerated 3D T2 mapping with dictionary-based matching for prostate imaging.

Elisa Roccia1, Rohini Vidya Shankar1, Radhouene Neji1,2

  • 1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

Magnetic Resonance in Medicine
|October 29, 2018
PubMed
Summary
This summary is machine-generated.

This study presents a rapid 3D T2 mapping technique for prostate cancer using undersampled MRI and dictionary fitting. The method achieves accurate T2 quantification in just 3 minutes, improving diagnostic speed.

Keywords:
3T MRIT2 mappingprostate cancer imagingquantitative MRI

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Medical Physics
  • Radiology

Background:

  • Accurate T2 mapping of the prostate is crucial for diagnosing prostate cancer.
  • Traditional MRI techniques can be time-consuming, limiting clinical applicability.
  • Developing faster and more precise methods for T2 quantification is an ongoing challenge in MRI research.

Purpose of the Study:

  • To develop and validate a fast and accurate 3D quantitative T2 mapping technique for the prostate.
  • To utilize undersampled acquisition and dictionary-based fitting for accelerated T2 mapping.
  • To enable rapid, high-resolution T2 quantification for improved prostate cancer assessment.

Main Methods:

  • Employed a 3D variable density undersampled Cartesian trajectory with a multishot T2-prepared balanced steady-state free precession (T2-prep-bSSFP) sequence.
  • Reconstructed T2-weighted images using total variation regularized sensitivity encoding.
  • Generated a dictionary of magnetization signals using extended phase graphs and matched it to acquired images for T2 value retrieval.

Main Results:

  • The proposed T2 mapping approach demonstrated robustness to noise and T1 variations in simulations.
  • T2 values from the T2-prep-bSSFP sequence highly correlated with gold-standard spin echo methods (r = 0.99).
  • Accelerated acquisition showed no significant difference compared to fully sampled acquisition (r = 0.99), with T2 values of 97 ± 14 ms (peripheral zone), 76 ± 7 ms (central gland), and 36 ± 3 ms (muscle) in healthy subjects.

Conclusions:

  • Achieved 3D quantitative T2 mapping of the entire prostate in just 3 minutes.
  • The developed method offers a fast and accurate approach for prostate T2 mapping.
  • This technique has the potential to enhance the speed and accuracy of prostate cancer diagnosis using MRI.