Related Experiment Video
Updated: Feb 3, 2026
02:15
Predictive Measurement for Windlass Change in Length and Selected Treatment Outcomes in Chronic Plantar Fasciitis
Published on: March 1, 2024
907
Predictive factors for poor outcome in pediatric C3 glomerulonephritis
Mamiko Hosoya1, Yukihiko Kawasaki1, Ryo Maeda1
1Department of Pediatrics, Fukushima Medical University School of Medicine.
Fukushima Journal of Medical Science
|October 30, 2018
Summary
Pediatric C3 glomerulonephritis (C3GN) severity at onset and ongoing complement activity predict poor outcomes. Early detection of these factors is crucial for managing pediatric C3GN.
Area of Science:
- Nephrology
- Pediatric Nephrology
- Immunology
Background:
- Pediatric C3 glomerulonephritis (C3GN) is a rare kidney disease.
- Predictive factors for poor outcomes in pediatric C3GN require clarification.
Purpose of the Study:
- To identify clinico-pathological factors associated with poor prognosis in pediatric C3GN.
- To evaluate the relationship between initial presentation and long-term outcomes.
Main Methods:
- Retrospective analysis of 18 pediatric C3GN patients.
- Classification into end-stage renal disease (ESRD) and non-ESRD groups.
- Comparison of clinical, laboratory, and histological findings.
Main Results:
- Higher frequency of nephrotic syndrome and elevated serum creatinine in the ESRD group.
- Increased urinary protein excretion and lower C3/CH50 levels in the ESRD group.
- Greater renal injury, mesangial deposits, and alpha SMA staining in the ESRD group.
Conclusions:
- Severity of C3GN at onset is a key predictor of poor prognosis.
- Persistent complement activity is linked to adverse outcomes in pediatric C3GN.
Related Concept Videos
02:24Predicting Reaction Outcomes
10.8K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K
02:27Predicting Molecular Geometry
45.8K
VSEPR Theory for Determination of Electron Pair Geometries
45.8K
01:13Outcomes of Glycolysis
107.2K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.2K
01:03Prediction Intervals
3.4K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
3.4K
01:11Guidelines for Writing Outcome
3.9K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
3.9K
02:16Transcription Factors
82.7K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.7K