Related Experiment Video

Updated: Feb 3, 2026

Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules
13:35

Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules

Published on: June 26, 2017

13.9K

Non-Diabetic Hyperglycemia in the Pediatric Age: Why, How, and When to Treat?

Valentina Fattorusso1, Rosa Nugnes1, Alberto Casertano1

  • 1Department of Translational Medical Science (DISMET), Section of Pediatrics, University of Naples Federico II, Naples, Italy.

Current Diabetes Reports
|October 30, 2018
PubMed

Insights

Non-diabetic hyperglycemia (NDHY) is a poorly understood condition. This review explores management strategies for transient hyperglycemia in non-diabetic individuals, especially children, often linked to stress or medications.

Area of Science:

  • Endocrinology
  • Pediatrics
  • Metabolic Disorders

Background:

  • Non-diabetic hyperglycemia (NDHY) is an under-recognized condition.
  • Transient hyperglycemia in children, termed stress hyperglycemia (SHY), is not well understood.
  • SHY can be categorized into SHY1 (severe illness) and SHY2 (non-life-threatening illness).

Purpose of the Study:

  • To review and examine management approaches for non-diabetic hyperglycemia.
  • To elucidate the biological effects of transient NDHY, particularly in pediatric populations.
  • To identify causes of drug-induced NDHY in children.

Main Methods:

  • Literature review of existing studies on NDHY.
  • Clinical practice analysis to classify SHY.
  • Identification of drug-induced hyperglycemia in pediatric patients.

Main Results:

  • NDHY is often transient and resolves after acute illness or stress.
  • Pediatric NDHY can be induced by steroid or antineoplastic/immunosuppressive therapies.
  • SHY occurs during acute illness, with distinct classifications based on severity.

Conclusions:

  • Further research is needed to understand the biological effects of NDHY.
  • Effective management strategies for NDHY require further investigation.
  • Recognizing NDHY triggers, including medications, is crucial for pediatric care.
Abstract

Keywords:
Drug-induced hyperglycemiaManagementNon-diabetic hyperglycemiaStress hyperglycemia

More Related Videos

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K
Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

1.0K

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.6K
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
703
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.5K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
262
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.1K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
500