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Metabolomics in Systems Biology
Syarul Nataqain Baharum1, Kamalrul Azlan Azizan2
1Institute of Systems Biology, Universiti Kebangsaan Malaysia (UKM), Bangi, Malaysia. nataqain@ukm.edu.my.
Advances in Experimental Medicine and Biology
|November 2, 2018
Summary
Metabolomics, a dynamic systems biology tool, analyzes downstream products unlike other omics. It uses nuclear magnetic resonance (NMR) and mass spectrometry (MS) for applications in human diseases, plant stress, and microbial biotechnology.
Area of Science:
- Systems Biology
- Metabolomics
- Omics Technologies
Background:
- Metabolomics is a rapidly growing field in systems biology, offering insights into complex phenotypes.
- It complements other omics (transcriptomics, proteomics) by analyzing downstream products, not just intermediate steps.
- Key technologies include nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), such as GC-MS and LC-MS.
Purpose of the Study:
- To discuss the concept of metabolomics within systems biology.
- To highlight the applications of metabolomics in diverse fields.
- To present case studies illustrating metabolomics analysis.
Main Methods:
- Utilizes high-throughput instruments like NMR and MS (GC-MS, LC-MS) for data generation.
- Employs discovery metabolomics for comprehensive data analysis.
- Applies metabolomics to study human diseases, plant stress responses, and microbial systems.
Main Results:
- Metabolomics provides a comprehensive view of biological systems by analyzing end products.
- Applications demonstrated in human disease research, plant abiotic stress, and microbial biotechnology.
- Case studies include Persicaria minor metabolome and microbial metabolic engineering.
Conclusions:
- Metabolomics is a powerful technology for elucidating complex phenotypes in systems biology.
- Its applications span human health, agriculture, and industrial biotechnology.
- Further case studies showcase its utility in specific research areas.
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