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Metabolic Engineering and Synthetic Biology
1Institute of Systems Biology, Universiti Kebangsaan Malaysia (UKM), Bangi, Malaysia. bazliramzi@ukm.edu.my.
Advances in Experimental Medicine and Biology
|November 2, 2018
Summary
Metabolic engineering and synthetic biology offer innovative platforms for bioproduct development. This chapter explores their application in waste bioconversion and the microbial production of valuable natural products.
Area of Science:
- Biotechnology
- Metabolic Engineering
- Synthetic Biology
Background:
- Next-generation genomics and the Fourth Industrial Revolution drive demand for translational research and product commercialization.
- Metabolic engineering and synthetic biology provide robust platforms for biotechnological innovation using microbial chassis.
- Biological engineering (BioE) components are crucial for advancing industrial and agricultural biotechnology.
Purpose of the Study:
- To introduce concepts of metabolic engineering, synthetic biology, and microbial chassis.
- To discuss BioE applications in industrial and agricultural biotechnology, focusing on waste bioconversion and value-added products.
- To highlight the integration of systems and synthetic biology for microbial natural product synthesis.
Main Methods:
- Exploration of metabolic engineering and synthetic biology principles.
- Discussion of strategies for waste bioconversion and value-added product development.
- Case study on integrating systems and synthetic biology for natural product biosynthesis in engineered yeast.
Main Results:
- Established metabolic engineering and synthetic biology as viable platforms for bioproduct development.
- Demonstrated strategies for waste bioconversion and the creation of value-added products.
- Showcased the potential of engineered yeast for producing natural products like flavonoids from Polygonum minus.
Conclusions:
- Metabolic engineering and synthetic biology are key enablers for innovation in biotechnology.
- BioE strategies facilitate efficient waste utilization and the development of high-value bioproducts.
- Integrating systems and synthetic biology holds significant promise for microbial production of complex natural products.
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