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Bone Health During the Menopause Transition and Beyond
Arun S Karlamangla1, Sherri-Ann M Burnett-Bowie2, Carolyn J Crandall3
1Division of Geriatrics, David Geffen School of Medicine at UCLA, 10945 Le Conte Avenue #2339, Los Angeles, CA 90095, USA.
Obstetrics and Gynecology Clinics of North America
|November 8, 2018
Summary
Women experience rapid bone loss during menopause, impacting bone strength and structure. Monitoring sex hormones and bone resorption markers can predict this bone loss and identify at-risk individuals.
Area of Science:
- Bone biology and skeletal health.
- Endocrinology and reproductive health.
Background:
- Menopause transition significantly impacts bone health, leading to rapid bone mass and strength loss.
- Bone microarchitecture and macrostructure undergo detrimental changes during this period.
Purpose of the Study:
- To investigate the changes in bone mass, macrostructure, and microarchitecture during menopause.
- To explore the predictive value of sex steroid hormones and bone resorption markers for rapid bone loss.
Main Methods:
- Analysis of bone mass, macrostructure, and microarchitecture changes.
- Measurement of sex steroid hormones and bone resorption markers.
Main Results:
- Rapid bone loss occurs within a 3-year window around the final menstrual period.
- Changes in bone strength indices, trabecular thickness, and connectivity reflect bone loss.
- Elevated bone resorption markers and altered sex steroid hormones precede rapid bone loss.
Conclusions:
- The menopause transition is a critical period for bone health, characterized by significant bone loss.
- Hormonal changes and increased bone resorption markers can predict the onset and severity of bone loss during menopause.
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