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Interception. IV: Failure of mifepristone (RU 486) as a monthly contragestive, "Lunarette"
Contraception
|May 1, 1987
Summary
The antiprogestin mifepristone (RU 486) was evaluated for continuous fertility control. However, it proved inadequate for monthly use, with two out of three conceptions continuing despite treatment.
Area of Science:
- Reproductive endocrinology
- Pharmacology
Background:
- Continuous fertility control methods are crucial for family planning.
- Antiprogestins represent a novel class of hormonal contraceptives.
Purpose of the Study:
- To assess the efficacy of mifepristone (RU 486) as a contragestive for continuous fertility control.
- To evaluate its effectiveness over 24 menstrual cycles.
Main Methods:
- Mifepristone was administered for continuous fertility control.
- The study monitored 24 menstrual cycles.
Main Results:
- Two out of three conceptions continued despite mifepristone treatment.
- The antiprogestin demonstrated inadequate efficacy for the intended use.
Conclusions:
- Mifepristone, at the doses studied, is not sufficiently effective for continuous monthly fertility control.
- Further research may be needed to determine optimal dosing or alternative applications.
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