Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Folding01:22

Protein Folding

127.4K
Overview
127.4K
Protein Folding01:25

Protein Folding

11.5K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
11.5K
Molecular Chaperones and Protein Folding03:00

Molecular Chaperones and Protein Folding

19.8K
The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
The...
19.8K
Molecular Chaperones and Protein Folding03:00

Molecular Chaperones and Protein Folding

15.0K
15.0K
Protein Complex Assembly02:41

Protein Complex Assembly

16.8K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.8K
Block Diagram Reduction01:22

Block Diagram Reduction

561
The process of deriving the transfer function of a control system often involves reducing its block diagram to a single block. This simplification can be achieved through a series of strategic operations, including relocating branch points and comparators. These operations preserve the overall function of the system while allowing for easier manipulation and combination of blocks.
The first step in this process is the identification and relocation of a branch point. A branch point, where a...
561

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ecoflex-hydrogel bilayer soft robot for pH-controlled drug protection and delivery.

Materials today. Bio·2026
Same author

3D Neuromodulation in Neural Organoids with Shell MEAs.

Advanced healthcare materials·2026
Same author

3D Spatiotemporal Electrophysiology of Cardiac Organoids Using Shell Microelectrode Arrays.

Advanced materials (Deerfield Beach, Fla.)·2025
Same author

Democratizing advanced surgical guidance: decoupling the state-of-the-art from tertiary centers and breaking trail for autonomous robotic surgery in austere environments.

Proceedings of SPIE--the International Society for Optical Engineering·2025
Same author

Computational modeling of necrosis in neural organoids.

bioRxiv : the preprint server for biology·2025
Same author

Data-Driven Printability Modeling of Hydrogels for Precise Direct Ink Writing Based on Rheological Properties.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same journal

Correction: Kang et al. Fluid Flow to Electricity: Capturing Flow-Induced Vibrations with Micro-Electromechanical-System-Based Piezoelectric Energy Harvester. <i>Micromachines</i> 2024, <i>15</i>, 581.

Micromachines·2026
Same journal

Femtosecond Laser Texturing of Wood Coatings with Bio-Based Epoxy and Wax Additives for Enhanced Hydrophobicity.

Micromachines·2026
Same journal

Engineering of Optoelectronic Devices for Renewable Energy Applications.

Micromachines·2026
Same journal

Phase Transformation and Electrochemical Behavior of Hexagonal TiO<sub>2</sub> Nanotubes Under Different Annealing Temperatures and Heating Rates.

Micromachines·2026
Same journal

Process Optimization and Predictive Modeling of Femtosecond Laser Precision Milling for Commercial PMMA Slices.

Micromachines·2026
Same journal

A Hybrid Preprocessing Multi-Objective Surrogate Model for Thermal MEMS Actuators.

Micromachines·2026
See all related articles

Related Experiment Video

Updated: Feb 2, 2026

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold
07:09

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Published on: October 26, 2018

6.6K

Assembly of a 3D Cellular Computer Using Folded E-Blocks.

Shivendra Pandey1, Nicholas J Macias2, Carmen Ciobanu3

  • 1Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA. shivendra@jhu.edu.

Micromachines
|November 9, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel 3D cellular computing architecture using electronic blocks (E-blocks). This scalable, defect-tolerant system enables the creation of highly compact, manufacture-ready 3D integrated circuits.

Keywords:
architecturecell matrixself-assemblyself-configurability

More Related Videos

Interactive Molecular Model Assembly with 3D Printing
06:15

Interactive Molecular Model Assembly with 3D Printing

Published on: August 13, 2020

10.9K
Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

12.4K

Related Experiment Videos

Last Updated: Feb 2, 2026

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold
07:09

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Published on: October 26, 2018

6.6K
Interactive Molecular Model Assembly with 3D Printing
06:15

Interactive Molecular Model Assembly with 3D Printing

Published on: August 13, 2020

10.9K
Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

12.4K

Area of Science:

  • Electrical Engineering
  • Computer Science
  • Materials Science

Background:

  • The increasing demand for advanced electronic devices necessitates novel architectures beyond traditional 2D designs.
  • Existing 3D integration methods, like stacking, have limitations in creating truly volumetric, cellular computing systems.
  • Developing scalable and defect-tolerant paradigms for 3D cellular computation remains a significant challenge.

Purpose of the Study:

  • To present the software and hardware foundations for a practical, truly 3D cellular computational device.
  • To introduce a scalable, self-configurable, and defect-tolerant cell matrix architecture.
  • To demonstrate a manufacturable approach for assembling 3D electronic systems.

Main Methods:

  • Development of a computing architecture based on a scalable cell matrix.
  • Utilization of folded polyhedral electronic blocks (E-blocks) for 3D assembly.
  • Creation and testing of monomer, dimer, and 2x2x2 E-block assemblies to verify computational capabilities.

Main Results:

  • Successful implementation of simple logic functions using the 3D cellular architecture.
  • Demonstration of a scalable and manufacturable process for 3D electronic block assembly.
  • Achieved 63.2% greater compactness in 3D circuits compared to 2D designs using automation tools.

Conclusions:

  • The presented work provides a proof-of-concept for truly 3D cellular computational devices.
  • The developed E-block system offers a scalable and manufacture-ready solution for massive-scale 3D integration.
  • This approach overcomes limitations of pseudo-3D architectures, paving the way for denser and more efficient electronics.