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Updated: Feb 2, 2026
03:57
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
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Total versus subtotal parathyroidectomy for secondary hyperparathyroidism.
Elin Isaksson1, Kerstin Ivarsson2, Shahriar Akaberi2
1Lund University, Faculty of Medicine, Department of Clinical Sciences, Nephrology, Malmö, Sweden.
Surgery
|November 11, 2018
Summary
Total parathyroidectomy increased cardiovascular events but decreased recurrent parathyroidectomy risk compared to subtotal surgery in patients with secondary hyperparathyroidism.
Area of Science:
- Nephrology
- Endocrinology
- Surgical Oncology
Background:
- Secondary hyperparathyroidism is common in patients with chronic kidney disease.
- The optimal surgical approach, total versus subtotal parathyroidectomy, remains debated.
- Outcomes of parathyroidectomy for secondary hyperparathyroidism require further investigation.
Purpose of the Study:
- To compare outcomes of total versus subtotal parathyroidectomy in patients on renal replacement therapy.
- To investigate differences in mortality, cardiovascular events, hip fracture, and recurrent parathyroidectomy.
Main Methods:
- Retrospective cohort study using Swedish national registries (1991-2013).
- Identified 824 patients undergoing parathyroidectomy for secondary hyperparathyroidism.
- Used COX regression to analyze adjusted risks of adverse outcomes.
Main Results:
- No significant difference in mortality or hip fracture risk between total and subtotal parathyroidectomy.
- Total parathyroidectomy was associated with a higher risk of cardiovascular events (HR 0.43; 0.25-0.72).
- Subtotal parathyroidectomy showed a higher risk of recurrent parathyroidectomy (HR 3.33; 1.33-8.32).
Conclusions:
- Total parathyroidectomy is linked to increased cardiovascular events but reduced need for reoperation.
- Subtotal parathyroidectomy may be preferred to avoid cardiovascular complications, despite a higher risk of recurrence.
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