Related Experiment Video

Updated: Feb 2, 2026

Study of the DNA Damage Checkpoint using Xenopus Egg Extracts
10:55

Study of the DNA Damage Checkpoint using Xenopus Egg Extracts

Published on: November 5, 2012

17.1K

Neuromuscular complications of immune checkpoint inhibitors

Dimitri Psimaras1

  • 1Sorbonne université, Inserm, CNRS, UMR S 1127, institut du cerveau et de la moelle épinière, ICM, AP-HP, hôpitaux universitaires La Pitié Salpêtrière - Charles Foix, service de neurologie 2-Mazarin, 75013 Paris, France; OncoNeuroTox Group, Center for Patients with Neurological Complications of Oncologic Treatments, Hôpitaux Universitaires Pitié-Salpetrière-Charles Foix et Hôpital Percy, 75013 Paris, France.

Presse Medicale (Paris, France : 1983)
|November 11, 2018
PubMed

Insights

Immune checkpoint inhibitors (ICIs) can cause rare but severe neurological immune-related adverse events (irAEs), primarily affecting the neuromuscular system. Early multidisciplinary recognition and treatment with immune-modulating therapies are crucial for better patient outcomes.

Area of Science:

  • Oncology
  • Neurology
  • Immunology

Background:

  • Immune checkpoint inhibitors (ICIs) are widely used cancer treatments.
  • While effective, ICIs can cause immune-related adverse events (irAEs).
  • Neurological irAEs are uncommon but serious complications of ICIs.

Purpose of the Study:

  • To highlight the occurrence and characteristics of neurological irAEs.
  • To emphasize the importance of early diagnosis and management.
  • To underscore the need for a multidisciplinary approach in managing these events.

Main Methods:

  • Review of existing literature on neurological irAEs associated with ICIs.
  • Analysis of clinical presentations and treatment responses.
  • Synthesis of information regarding diagnostic challenges and therapeutic strategies.

Main Results:

  • Neuromuscular complications are the most frequent type of neurological irAE.
  • These events represent a distinct category of neurologic complications from systemic anticancer therapies.
  • Many neurological irAEs show responsiveness to immune-modulating treatments.

Conclusions:

  • Neurological irAEs are rare but severe adverse events associated with ICIs.
  • Prompt identification and intervention are critical for improving functional outcomes.
  • A collaborative, multidisciplinary approach is essential for optimal patient care.

More Related Videos

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes10:09

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes

Published on: September 13, 2022

2.6K
Measuring Neuromuscular Junction Functionality10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

18.7K

Related Concept Videos

The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
3.8K
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.0K
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
821
What is the Immune System?01:38

What is the Immune System?

Overview
128.1K
The Neuromuscular Junction01:19

The Neuromuscular Junction

The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
19.0K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
861