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Functional mapping and effective connectivity of the human operculum.
Mihai-Dragoş Mălîia1, Cristian Donos2, Andrei Barborica3
1Neurology Department, University Emergency Hospital, Bucharest, Romania; Physics Department, University of Bucharest, Bucharest, Romania.
Summary
This study maps the operculum
Area of Science:
- Neuroscience, Neurophysiology, Brain Mapping
Background:
- The operculum, adjacent to the insula, plays a role in neurologic and psychiatric conditions.
- Its functions include sensory, motor, autonomic, cognitive, and language processing.
Purpose of the Study:
- To detail the functional mapping and effective connectivity of the human operculum.
- To distinguish opercular functions from those of the insular cortex.
Main Methods:
- Intracranial electrode stimulation in 31 epilepsy patients (non-epileptogenic opercular cortex).
- Electrical stimulation (1 Hz and 50 Hz) to evoke clinical effects.
- Cortico-cortical evoked potentials to assess effective connectivity in 19 patients.
Main Results:
- Frontal operculum stimulation yielded language effects (29%).
- Rolandic area: oropharyngeal symptoms (47%); parietal operculum: somatosensory effects (67%); temporal operculum: auditory effects (58%).
- Complex connectivity with widespread ipsilateral/contralateral projections and consistent local connections.
Conclusions:
- Demonstrates specific opercular functionality distinct from the insula.
- Provides a detailed map of the opercular functional connectome.
Keywords:
Brain stimulationEffective connectivityFunctional mappingOperculumStereoelectroencephalographyMore Related Videos
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