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Necrotizing Fasciitis: An Overview and 2 Illustrative Cases

Daniel L Kapp1, Montanah Rogers2, Michel H E Hermans3

  • 11 Jupiter Medical Center, Jupiter, FL, USA.

The International Journal of Lower Extremity Wounds
|November 14, 2018
PubMed

Insights

Necrotizing fasciitis is a severe skin infection requiring surgical removal of dead tissue. A hyaluronic-based matrix shows promise for preparing large surgical defects for skin grafting.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Regenerative Medicine

Background:

  • Necrotizing fasciitis is a rapidly progressive, life-threatening infection of the skin and subcutaneous tissue.
  • Standard treatment involves aggressive surgical debridement of necrotic tissue and systemic support.
  • Large resulting defects often necessitate complex wound closure strategies, including autografts.

Observation:

  • The study reviews symptoms and treatment of necrotizing fasciitis.
  • Two case studies demonstrate the application of a hyaluronic-based extracellular matrix.
  • This matrix is used to reconstruct lost dermal tissue and prepare the wound bed.

Findings:

  • The hyaluronic-based extracellular matrix effectively promotes neodermis formation.
  • It creates a suitable wound bed environment for subsequent autografting.
  • This approach addresses challenges associated with large defects post-debridement.

Implications:

  • Hyaluronic-based matrices offer a potential adjunct in managing extensive necrotizing fasciitis defects.
  • This regenerative approach may improve outcomes and reduce morbidity associated with large-scale debridement.
  • Further research can explore the long-term efficacy and broader applications of extracellular matrices in reconstructive surgery.
Keywords:
diagnosisextracellular matrixhyaluronic acidnecrotizing fasciitistreatment

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