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Ellipsoidal particles for liquid chromatography: Fluid mechanics, efficiency and wall effects
Mark R Schure1, Robert S Maier2
1Theoretical Separation Science Laboratory, Kroungold Analytical Inc., 1299 Butler Pike, Blue Bell, PA 19422, United States.
Journal of Chromatography. A
|November 16, 2018
Summary
Ellipsoidal particles show promise for liquid chromatography, offering reduced wall effects in capillaries. However, simulations indicate they are less efficient than spherical particles in beds without wall effects.
Area of Science:
- Analytical Chemistry
- Chemical Engineering
- Computational Science
Background:
- Spherical particles are standard in liquid chromatography packing.
- Investigating alternative particle shapes can optimize chromatographic performance.
Purpose of the Study:
- To evaluate ellipsoidal particles as packing media for liquid chromatography.
- To compare their performance against spherical particles using simulations.
Main Methods:
- High-resolution fluid mechanics and Brownian dynamics simulations.
- Simulations conducted in packed capillary columns and beds with periodic boundary conditions (PBCs).
- Analysis of transport, separation impedance, plate height, and pressure drop.
Main Results:
- Ellipsoidal particle packs showed inferior chromatographic dispersion compared to sphere packs using PBCs.
- Separation impedance was similar for both particle types under PBCs.
- Ellipsoidal particles exhibited smaller wall effects in capillary columns, with reduced radial variations in porosity and flow.
Conclusions:
- Ellipsoidal particles demonstrate potential advantages over spherical particles in packed capillaries due to reduced wall effects.
- Further experimental validation is needed to confirm the predicted performance benefits.
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