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A Scalable Optoelectronic Neural Probe Architecture With Self-Diagnostic Capability.

Hubin Zhao1,2, Ahmed Soltan3, Pleun Maaskant4

  • 11Newcastle UniversityNewcastle upon TyneNE1 7RUU.K.

IEEE Transactions on Circuits and Systems. I, Regular Papers : a Publication of the IEEE Circuits and Systems Society
|November 20, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a new implantable optoelectronics device for neuroscience and optogenetics. This miniaturized device offers multi-site optical stimulation with diagnostic sensing for safe, long-term neurological disorder treatments.

Keywords:
Active optrodeimplantableneural stimulationoptogeneticsself-diagnostic

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Optoelectronics

Background:

  • Growing demand for advanced implantable optoelectronics in neuroscience and optogenetics.
  • Need for devices supporting multi-site optical stimulation, programmable radiance, safety, and miniaturization.
  • Preference for simple serial interfaces over numerous control lines.

Purpose of the Study:

  • To demonstrate a novel optrode structure for advanced optogenetic applications.
  • To integrate multi-site optical stimulation and diagnostic sensing capabilities.
  • To enable independent control and serial communication for external units.

Main Methods:

  • Utilized a standard complementary metal-oxide-semiconductor (CMOS) process.
  • Integrated 18 optical stimulation drivers within the optrode structure.
  • Incorporated diagnostic sensing circuitry for long-term functionality assessment.
  • Developed a digital control system for independent multi-site control and serial communication.

Main Results:

  • Successfully demonstrated an optrode structure with 18 optical stimulation drivers.
  • Integrated diagnostic sensing circuitry to monitor photonic element functionality.
  • Implemented a digital control system enabling independent multi-site control and serial communication.

Conclusions:

  • The developed optrode structure meets key specifications for implantable optoelectronics.
  • The integrated diagnostic sensing and digital control enhance device safety and usability.
  • This technology supports advancements in basic neuroscience research and optogenetic therapies for neurological disorders.