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Updated: Feb 2, 2026
09:20
Isolation and Differentiation of Adipose-Derived Stem Cells from Porcine Subcutaneous Adipose Tissues
Published on: March 31, 2016
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Adipose-Derived Stem Cell Treatments and Formulations
Berardo Di Matteo1, Mohamed Marzouk El Araby1, Alessandro D'Angelo2
1Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, Rozzano, Milan 20089, Italy; Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milan 20089, Italy.
Clinics in Sports Medicine
|November 24, 2018
Summary
Evidence for adipose-derived stem cells (ASCs) in cartilage repair is limited. Current studies, mostly short-term case series, lack high-quality data, and no optimal preparation method is established for treating cartilage pathology.
Area of Science:
- Regenerative Medicine
- Orthopedics
- Stem Cell Therapy
Background:
- Cartilage pathology presents a significant clinical challenge.
- Adipose-derived stem cells (ASCs) show promise for tissue regeneration.
- Current evidence on ASCs for cartilage repair requires critical evaluation.
Purpose of the Study:
- To systematically review and analyze the existing literature on the therapeutic potential of ASCs in cartilage pathology.
- To assess the quality of evidence and identify trends in ASC application for cartilage repair.
Main Methods:
- A comprehensive literature search was conducted.
- Seventeen relevant articles were identified and analyzed.
- The review focused on study design, cell preparation, administration route, and outcome measures.
Main Results:
- A significant lack of high-quality evidence supports the use of ASCs for cartilage pathology.
- Most included studies were case series with limited follow-up periods.
- Intra-articular injection of the stromal vascular fraction (SVF) was more common than using expanded ASCs.
Conclusions:
- The current evidence base for ASCs in treating cartilage pathology is insufficient.
- No definitive preparation method or formulation is currently recommended for clinical practice.
- Further high-quality, long-term studies are needed to establish the efficacy and safety of ASCs in cartilage repair.
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