[Recent data on the mechanism of action of theophylline]

Since Sutherland's work simply based on the inhibition of phosphodiesterase was questioned, other researches have been carried out, indicating that many mechanisms located in the nervous system, the smooth muscle, and the immunity system interfere. The participation of receptors to adenosine, intracellular calcium ions, regulating calciproteins and autacoids such as prostaglandins was the purpose of numerous experimental researches that allow today to fill up the gap left by the fact that the inhibitor of phosphodiesterase was questioned. However, there are not sufficient but there are many seducing research and hypotheses.