Area of Science:

• Oncology
• Gastroenterology
• Surgical Oncology

Background:

• Pancreatic tumors necessitate complex surgical interventions.
• Total pancreatectomy (TP) is a radical procedure for advanced pancreatic malignancies.
• Evaluating TP outcomes is crucial for patient management.

Purpose of the Study:

• To analyze lethality, morbidity, survival, and metabolic consequences of total pancreatectomy (TP).
• To assess the feasibility and outcomes of TP in a Ukrainian specialized center.

Main Methods:

• Retrospective analysis of 35 total pancreatectomy (TP) operations.
• Inclusion of both urgent and elective TP procedures.
• Evaluation of post-operative lethality, complications, survival rates, and metabolic sequelae.

Main Results:

• Overall lethality was 20% (7/35), with elective TP showing lower lethality (6.7%, 2/30).
• Complication rate for elective TP was 40%.
• Median survival was 18 months, with 3-year survival at 40% and 5-year survival at 13.3%.

Conclusions:

• Total pancreatectomy (TP) is a viable option in specialized Ukrainian centers, with outcomes comparable to international standards.
• Pancreatic exocrine insufficiency, pancreatogenic diabetes, and lipid metabolism changes are frequent post-TP metabolic consequences.
• Elective TP demonstrates improved survival and reduced lethality compared to urgent TP.