Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.2K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.2K
Protein Networks02:26

Protein Networks

4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
Regulated mRNA Transport02:22

Regulated mRNA Transport

7.0K
In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
7.0K
Conjugated Proteins02:50

Conjugated Proteins

28.7K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
28.7K
Retroviruses02:33

Retroviruses

15.0K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
15.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exosomes in Dermatology.

Skin therapy letter·2026
Same author

Enhanced Home-Based Wart Treatment Protocol: Optimizing Debridement and Occlusion Therapy for Improved Outcomes.

Advances in skin & wound care·2026
Same author

Herpes Zoster Risk in the Era of Targeted Immunotherapy: JAK Inhibitors Versus Biologics.

Journal of cutaneous medicine and surgery·2026
Same author

Acquired Epidermodysplasia Verruciformis in Patients with Iatrogenic Immunosuppression.

Journal of clinical medicine·2026
Same author

A novel oral interleukin-23 receptor antagonist peptide, icotrokinra, for moderate-to- severe plaque psoriasis: a systematic review and meta-analysis of randomized controlled trials.

Inflammopharmacology·2026
Same author

Nemolizumab as an Alternative Therapeutic Option for Indolent Systemic Mastocytosis.

Cureus·2026
Same journal

Clinical Trials and Translational Advances in Metabolic Targeting.

Cancer treatment and research·2026
Same journal

Tools and Technologies for Studying Cancer Metabolism.

Cancer treatment and research·2026
Same journal

Cancer and Immune Cells: A Metabolic Battle in the Tumor Microenvironment.

Cancer treatment and research·2026
Same journal

Biomarkers of Cancer Metabolism and Therapeutic Response.

Cancer treatment and research·2026
Same journal

Targeting Metabolism in Cancer Therapy: Inhibitors and Approaches.

Cancer treatment and research·2026
Same journal

Metabolic Reprogramming in Cancer Stem Cells.

Cancer treatment and research·2026
See all related articles

Related Experiment Video

Updated: Feb 1, 2026

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish
08:32

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Published on: February 22, 2019

7.5K

AIDS-Associated Malignancies.

Ramya Vangipuram1, Stephen K Tyring2

  • 1Department of Dermatology, University of Texas Health Sciences Center at Houston, Houston, TX, 77030, USA.

Cancer Treatment and Research
|December 8, 2018
PubMed
Summary
This summary is machine-generated.

Acquired immune deficiency syndrome (AIDS) malignancies are often linked to viral coinfections like Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8). Highly active antiretroviral therapy (HAART) has reduced some cancers but has less impact on EBV- and HPV-related malignancies.

Keywords:
AIDS-associated lymphomaAnogenital cancerEpstein–Barr virusHuman herpesvirus 8Human immunodeficiency virusHuman papillomavirusKaposi sarcoma

More Related Videos

Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy
05:24

Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy

Published on: January 10, 2025

888
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

1.0K

Related Experiment Videos

Last Updated: Feb 1, 2026

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish
08:32

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Published on: February 22, 2019

7.5K
Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy
05:24

Multifractal Spectrum Analysis for Assessing Pulmonary Nodule Malignancy

Published on: January 10, 2025

888
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

1.0K

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Malignancies are key indicators of acquired immune deficiency syndrome (AIDS).
  • Most AIDS-related cancers stem from coinfections with oncogenic viruses, including Epstein-Barr virus (EBV), human herpesvirus 8 (HHV-8), and human papillomavirus (HPV).
  • Diminished immune surveillance in AIDS patients facilitates viral oncogenesis and tumor cell proliferation.

Purpose of the Study:

  • To provide an overview of HIV-associated malignancies mediated by HHV-8, EBV, and HPV.
  • To review the impact of highly active antiretroviral therapy (HAART) on the epidemiology, presentation, treatment, and outcomes of these cancers.
  • To highlight the differential effects of HAART on various AIDS-related malignancies.

Main Methods:

  • Literature review and synthesis of existing data on HIV-associated malignancies.
  • Analysis of the role of specific oncogenic viruses (HHV-8, EBV, HPV) in cancer development in HIV-infected individuals.
  • Examination of the influence of HAART on the incidence, management, and prognosis of these cancers.

Main Results:

  • HHV-8 is associated with Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD).
  • EBV is linked to Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), with over 50% of AIDS lymphomas associated with EBV and/or HHV-8.
  • HIV and HPV coinfection increases the risk of squamous cell carcinomas.
  • HAART has significantly reduced the incidence of KS and primary CNS lymphoma by suppressing HIV and restoring immune function.
  • HAART has shown less favorable effects on EBV- and HPV-related malignancies.

Conclusions:

  • HAART has profoundly altered the landscape of AIDS-related malignancies, with significant benefits for virally mediated cancers like KS.
  • The impact of HAART is less pronounced for EBV- and HPV-driven cancers, necessitating continued research and tailored treatment strategies.
  • Understanding the interplay between HIV, oncogenic viruses, and immune status is crucial for managing AIDS-related malignancies effectively.