Related Experiment Video

Updated: Feb 1, 2026

Single-Cell Multiplexed Fluorescence Imaging to Visualize Viral Nucleic Acids and Proteins and Monitor HIV, HTLV, HBV, HCV, Zika Virus, and Influenza Infection
07:24

Single-Cell Multiplexed Fluorescence Imaging to Visualize Viral Nucleic Acids and Proteins and Monitor HIV, HTLV, HBV, HCV, Zika Virus, and Influenza Infection

Published on: October 29, 2020

3.2K

HIV-HBV and HIV-HCV Coinfection and Liver Cancer Development

Jianming Hu1, Kuancheng Liu2, Jun Luo2

  • 1Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA. juh13@psu.edu.

Cancer Treatment and Research
|December 8, 2018
PubMed

Insights

Hepatitis B (HBV) and C (HCV) liver diseases, including cancer, are growing concerns for HIV patients. Effective antiviral therapies offer hope but require careful selection for coinfected individuals.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Hepatitis B (HBV), C (HCV), and human immunodeficiency virus (HIV) share transmission routes, leading to common coinfections.
  • HIV-induced immunodeficiency increases HBV and HCV persistence, while anti-HIV drugs can cause liver damage.

Purpose of the Study:

  • To review the impact of HIV on HBV/HCV-related liver diseases, including hepatocellular carcinoma (HCC).
  • To discuss the implications of current antiviral therapies for coinfected patients.

Main Methods:

  • Literature review of studies on HIV/HBV, HIV/HCV, and HIV/HBV/HCV coinfections.
  • Analysis of disease progression, hepatocarcinogenesis, and treatment outcomes.

Main Results:

  • HIV coinfection elevates the risk of HBV/HCV persistence and progression to cirrhosis and HCC.
  • Hepatotoxicity from anti-HIV therapy can exacerbate liver disease in coinfected individuals.
  • Successful HCV cure and effective HIV/HBV suppression are achievable with judicious therapy selection.

Conclusions:

  • Managing liver disease in coinfected patients requires careful consideration of shared transmission and treatment interactions.
  • Advances in antiviral therapy provide hope but necessitate strategic treatment choices for optimal patient outcomes.

Keywords:
CoinfectionHBVHCCHCVHIVHepatitis B virusHepatitis C virusHepatocellular carcinomaHuman immunodeficiency virus

More Related Videos

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

18.4K
Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis10:12

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis

Published on: September 11, 2019

9.1K

Related Concept Videos

Liver Histology01:27

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
4.4K
Liver Physiology01:30

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.7K
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.3K
Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
2.1K
Sustainable Development01:43

Sustainable Development

As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.1K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.0K