Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Potentiometric Titration: Overview01:31

Potentiometric Titration: Overview

4.3K
Potentiometric titration is a quantitative analytical technique that determines the concentration of an analyte by measuring the potential difference between the two electrodes in the solution. The endpoint of a potentiometric titration is the point at which there is a significant change in the potential difference. It occurs when the stoichiometric reaction between the analyte and the titrant is complete. The endpoint is usually determined graphically by plotting the measured potential...
4.3K
Metallic Solids02:37

Metallic Solids

20.6K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.6K
Structures of Solids02:22

Structures of Solids

17.7K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
17.7K
Regulation of Sodium and Potassium01:26

Regulation of Sodium and Potassium

2.3K
The regulation of sodium and potassium ion concentrations in the human body is a complex process governed primarily by hormones such as aldosterone, antidiuretic hormone (ADH), and atrial natriuretic peptide (ANP).
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
2.3K
Network Covalent Solids02:18

Network Covalent Solids

16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

8.0K
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lithographic patterning of conformal thin films on 3D structures using Scaffold-architected Lift-off masks.

Nature communications·2026
Same author

Self-Healing Antifouling Hydrogel Sensors Enabling Long-Term Monitoring of Potassium Ions in Marine Environments.

ACS sensors·2026
Same author

3D-Printed Hollow Microneedle Potentiometric Sensors: A Modular Approach.

ACS sensors·2026
Same author

Scalable Fabrication of 4 nm Silicon Nanopores by Self-Limiting Metal-Assisted Chemical Etching Combined with Optical Process Control.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Nanoelectroanalysis with Carbon Nanopipettes Based on Prussian Blue-NiHCF for Hydrogen Peroxide Sensing.

Analytical chemistry·2026
Same author

Fully 3D-Printed Analytical Device Based on a Novel Floating Electrode Mechanism for Sweat Rate Acquisition.

ACS measurement science au·2026

Related Experiment Video

Updated: Feb 1, 2026

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

3.6K

Wearable All-Solid-State Potentiometric Microneedle Patch for Intradermal Potassium Detection.

Marc Parrilla1, María Cuartero1, Sara Padrell Sánchez2,3

  • 1Department of Chemistry, School of Engineering Science in Chemistry, Biochemistry and Health , KTH Royal Institute of Technology , Teknikringen 30 , SE-100 44 Stockholm , Sweden.

Analytical Chemistry
|December 14, 2018
PubMed
Summary

A novel all-solid-state microneedle sensor enables painless, intradermal detection of potassium in interstitial fluid. This technology offers a resilient and reproducible method for monitoring electrolyte imbalances and related diseases.

More Related Videos

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

15.0K
Exploring Arterial Smooth Muscle Kv7 Potassium Channel Function using Patch Clamp Electrophysiology and Pressure Myography
11:02

Exploring Arterial Smooth Muscle Kv7 Potassium Channel Function using Patch Clamp Electrophysiology and Pressure Myography

Published on: September 14, 2012

16.2K

Related Experiment Videos

Last Updated: Feb 1, 2026

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

3.6K
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

15.0K
Exploring Arterial Smooth Muscle Kv7 Potassium Channel Function using Patch Clamp Electrophysiology and Pressure Myography
11:02

Exploring Arterial Smooth Muscle Kv7 Potassium Channel Function using Patch Clamp Electrophysiology and Pressure Myography

Published on: September 14, 2012

16.2K

Area of Science:

  • Analytical Chemistry
  • Biomedical Engineering
  • Materials Science

Background:

  • Electrolyte imbalance monitoring is crucial for managing various diseases.
  • Current methods for interstitial fluid analysis are often invasive or lack real-time capabilities.
  • Development of minimally invasive biosensors is essential for continuous health monitoring.

Purpose of the Study:

  • To present a new analytical all-solid-state platform for intradermal potentiometric detection of potassium.
  • To develop and characterize microneedle-based electrodes for accurate potassium measurement in interstitial fluid.
  • To evaluate the performance, safety, and applicability of the developed sensor for in vivo and ex vivo monitoring.

Main Methods:

  • Fabrication of solid microneedles modified with selective coatings and polymeric membranes for potassium-selective and reference electrodes.
  • Integration of microneedle electrodes into an epidermal patch for painless skin insertion.
  • Potentiometric analysis of analytical performances including Nernstian slope, limit of detection, linear range, drift, selectivity, and response time.
  • Evaluation of sensor resiliency through multiple insertions into animal skin and ex vivo testing on chicken and porcine skin.
  • In vitro cytotoxicity assessment for prolonged skin contact.

Main Results:

  • The microneedle sensor demonstrated a Nernstian slope, limit of detection of 10-4.9 potassium activity, and a linear range of 10-4.2 to 10-1.1.
  • The sensor exhibited fast response time, adequate selectivity, excellent reproducibility, and repeatability.
  • The potentiometric response remained stable after multiple insertions, confirming sensor resiliency.
  • Ex vivo tests confirmed suitability for monitoring potassium changes within the skin.
  • In vitro tests showed no cytotoxicity for up to 24 hours of use.

Conclusions:

  • The developed all-solid-state microneedle platform is a promising advancement for intradermal potassium analysis.
  • The sensor's performance and safety profile make it suitable for clinical applications and monitoring electrolyte imbalances.
  • This technology offers a minimally invasive approach for continuous health monitoring relevant to disease management.