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Updated: Feb 1, 2026

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
Chemoenzymatic Dynamic Kinetic Resolution of Amines in Fully Continuous-Flow Mode
Emese Farkas1, Márk Oláh1, Attila Földi1
1Department of Organic Chemistry and Technology , Budapest University of Technology and Economics , Műegyetem rkp. 3 , H-1111 Budapest , Hungary.
Abstract:
In this study, lipase-mediated dynamic kinetic resolution (DKR) of various benzylic amines (1a-g) is presented which is realized in a so far unprecedented fully continuous-flow system. The DKR process applying sol-gel immobilized lipase B from Candida antarctica as biocatalyst, palladium on 3-aminopropyl-functionalized silica as racemization catalyst, isopropyl 2-ethoxyacetate as acylating agent, ammonium formate as hydrogen and nitrogen sources, and 2-methyl-2-butanol as solvent under regulated pressure provided the desired products in moderate to good yields with excellent enantiomeric excesses.
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