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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
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[Sickle cell disease: A diagnosis to keep in mind]
Pamela Zúñiga C1, Cindy Martínez G2, Lina M González R3
1División de Pediatría, Pontificia Universidad Católica de Chile, Santiago, Chile.
Revista Chilena De Pediatria
|December 21, 2018
Summary
Sickle cell disease (SCD), a genetic blood disorder, is increasingly seen in Chile due to migration. Early diagnosis and management are crucial for preventing complications in at-risk patients.
Area of Science:
- Genetics and Hematology
- Molecular Biology
- Public Health
Background:
- Sickle cell disease (SCD) is the most common inherited hemoglobinopathy globally.
- It stems from genetic alterations in globin chain genes, causing red blood cell abnormalities.
- SCD is considered rare in Chile, with limited prevalence data.
Purpose of the Study:
- To review current knowledge on SCD physiopathology.
- To highlight recent guidelines and consensus on SCD diagnosis and management.
- To raise awareness of increasing SCD incidence in Chile due to migration.
Main Methods:
- Literature review of recent publications.
- Analysis of guidelines and consensus documents.
- Synthesis of information on physiopathology, diagnosis, and management.
Main Results:
- SCD incidence is rising in Chile, necessitating clinical consideration.
- Updated understanding of SCD physiopathology is available.
- Recent diagnostic and management guidelines exist.
Conclusions:
- SCD requires consideration in Chilean patients with anemia, especially given rising incidence.
- Knowledge of SCD physiopathology, diagnosis, and management is evolving.
- Adherence to updated guidelines is essential for patient care.
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