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Pattern Dystrophy.

Stephen H Tsang1,2, Tarun Sharma3

  • 1Jonas Children's Vision Care, Bernard & Shirlee Brown Glaucoma Laboratory, Columbia Stem Cell Initiative-Departments of Ophthalmology, Biomedical Engineering, Pathology & Cell Biology, Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Advances in Experimental Medicine and Biology
|December 23, 2018
PubMed
Summary
This summary is machine-generated.

Pattern dystrophies of the retinal pigment epithelium (RPE) are a group of inherited retinal diseases. This category includes butterfly-type, adult-onset foveomacular vitelliform, Sjögren

Keywords:
Autosomal dominantPattern dystrophy

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Area of Science:

  • Ophthalmology
  • Genetics
  • Retinal Diseases

Background:

  • Pattern dystrophies of the retinal pigment epithelium (RPE) represent a spectrum of inherited retinal disorders.
  • These conditions are characterized by specific deposition patterns within the RPE layer of the retina.

Purpose of the Study:

  • To outline the classification and key features of various pattern dystrophies of the RPE.
  • To provide a foundational understanding of these distinct retinal conditions.

Main Methods:

  • Review of existing literature and diagnostic criteria for pattern dystrophies.
  • Clinical and histopathological descriptions of different subtypes.

Main Results:

  • Identification of distinct pattern dystrophies: Butterfly-type pattern dystrophy, Adult-onset foveomacular vitelliform dystrophy, Sjögren's reticular-type pattern dystrophy, and Fundus pulverulentus.
  • These disorders share RPE abnormalities but differ in morphology and clinical presentation.

Conclusions:

  • Pattern dystrophies of the RPE comprise a heterogeneous group of diseases.
  • Accurate classification is crucial for understanding disease progression and potential management strategies.