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Updated: Jan 31, 2026

A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy

A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy

Published on: December 29, 2017

Occult Macular Dystrophy.

Stephen H Tsang^1,2, Tarun Sharma³

¹Jonas Children's Vision Care, Bernard & Shirlee Brown Glaucoma Laboratory, Columbia Stem Cell Initiative-Departments of Ophthalmology, Biomedical Engineering, Pathology & Cell Biology, Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Advances in Experimental Medicine and Biology

|December 23, 2018

Summary

This summary is machine-generated.

Occult macular dystrophy (OMD) causes progressive central vision loss in middle-aged adults. Diagnosis relies on optical coherence tomography (OCT) showing ellipsoid band loss, despite normal fundus exams.

Keywords:

Autosomal dominant Occult macular dystrophy

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Area of Science:

Ophthalmology
Medical Imaging
Retinal Diseases

Background:

Occult macular dystrophy (OMD) presents with progressive central vision loss.
Patients often experience central scotoma.
Fundus examination and fluorescein angiography typically show no significant abnormalities.

Purpose of the Study:

To describe the clinical presentation and diagnostic findings of occult macular dystrophy.
To highlight the utility of optical coherence tomography (OCT) in diagnosing OMD.
To correlate electroretinography (ERG) findings with OMD.

Main Methods:

Review of patient cases with suspected OMD.
Optical coherence tomography (OCT) imaging of the macula.
Full-field electroretinography (ffERG) and multifocal electroretinography (mfERG) testing.

Main Results:

OCT revealed loss of the ellipsoid band in the central macula.
Full-field ERG was normal or showed reduced cone response.
Multifocal ERG demonstrated diminished central retinal amplitude.

Conclusions:

OMD is characterized by central vision loss with subtle funduscopic findings.
OCT is crucial for identifying the ellipsoid band disruption in OMD.
ERG may show specific patterns indicative of cone dysfunction in OMD.