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Updated: Jan 31, 2026

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
09:45

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering

Published on: January 24, 2025

7.0K

Syphilis.

Stephen H Tsang1,2, Tarun Sharma3

  • 1Jonas Children's Vision Care, Bernard & Shirlee Brown Glaucoma Laboratory, Columbia Stem Cell Initiative-Departments of Ophthalmology, Biomedical Engineering, Pathology & Cell Biology, Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Advances in Experimental Medicine and Biology
|December 23, 2018
PubMed
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Syphilis, caused by Treponema pallidum, is a sexually transmitted infection with varied symptoms, often affecting the eyes. Congenital syphilis presents with distinct features like Hutchinson's teeth and potential vision impairment.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Syphilis is an infectious disease caused by the spirochete Treponema pallidum.
  • It is primarily transmitted sexually and is known as the "Great Imitator" due to its diverse systemic manifestations.
  • Ocular involvement is common in syphilis, with syphilitic uveitis being the most frequent presentation.

Purpose of the Study:

  • To summarize the key clinical manifestations of syphilis, particularly ocular involvement.
  • To highlight the diagnostic challenges posed by the variable presentation of syphilis.
  • To describe the characteristic features of congenital syphilis.

Main Methods:

  • Literature review of syphilis, focusing on clinical presentations and ocular manifestations.
Keywords:
PhenocopiesSyphilis

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Last Updated: Jan 31, 2026

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
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  • Analysis of case studies and epidemiological data related to Treponema pallidum infections.
  • Synthesis of information on congenital syphilis symptoms and ocular findings.

    • Main Results:

    • Syphilis can affect any part of the eye, with uveitis being the most common ocular manifestation.
    • Congenital syphilis is associated with specific physical deformities such as Hutchinson's teeth and saddle nose.
    • Retinal pigmentary changes in congenital syphilis are typically patchy and varied.

    Conclusions:

    • Syphilis requires a high index of suspicion due to its "Great Imitator" nature.
    • Ophthalmologists should consider syphilis in the differential diagnosis of uveitis and other ocular inflammatory conditions.
    • Early diagnosis and treatment of both acquired and congenital syphilis are crucial to prevent long-term complications, including vision loss.