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Related Concept Videos

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

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Related Experiment Video

Updated: Jan 31, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

Autoimmune Retinopathy.

Stephen H Tsang^1,2, Tarun Sharma³

¹Jonas Children's Vision Care, Bernard & Shirlee Brown Glaucoma Laboratory, Columbia Stem Cell Initiative-Departments of Ophthalmology, Biomedical Engineering, Pathology & Cell Biology, Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Advances in Experimental Medicine and Biology

|December 23, 2018

Summary

This summary is machine-generated.

Autoimmune retinopathies (AIRs) cause unexplained vision loss due to retinal inflammation and autoantibodies. Diagnosis involves visual field defects, electroretinography (ERG), and antibody testing.

Keywords:

Autoimmune retinopathy Phenocopies

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Area of Science:

Ophthalmology
Immunology
Retinal Diseases

Background:

Autoimmune retinopathies (AIRs) are inflammatory conditions causing progressive vision loss.
AIRs are characterized by photoreceptor dysfunction and circulating autoantibodies against retinal antigens.

Purpose of the Study:

To define the clinical and diagnostic features of autoimmune retinopathies.
To improve understanding of the pathophysiology and presentation of AIRs.

Main Methods:

Clinical case review and analysis of diagnostic findings.
Electroretinography (ERG) to assess photoreceptor function.
Serological testing for autoantibodies against retinal antigens.

Main Results:

Patients present with central and peripheral visual loss, visual field defects, and ring scotomas.
Electroretinography (ERG) typically shows reduced or absent responses.
Circulating autoantibodies against retinal antigens are a key diagnostic marker.

Conclusions:

AIRs are a distinct group of immune-mediated retinal diseases.
Early diagnosis and identification of autoantibodies are crucial for management.
Further research is needed to elucidate specific antigenic targets and treatment strategies.