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Related Experiment Video

Updated: Jan 31, 2026

Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery

Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery

Published on: March 4, 2021

Drug-Induced Retinal Toxicity.

Stephen H Tsang^1,2, Tarun Sharma³

¹Jonas Children's Vision Care, Bernard & Shirlee Brown Glaucoma Laboratory, Columbia Stem Cell Initiative-Departments of Ophthalmology, Biomedical Engineering, Pathology & Cell Biology, Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Advances in Experimental Medicine and Biology

|December 23, 2018

Summary

This summary is machine-generated.

Systemic, intravitreal, and topical medications can cause drug-induced retinal toxicity, damaging the retina despite the blood-ocular barrier. This toxicity affects various retinal components, leading to degeneration and dysfunction.

Keywords:

Drug-induced retinal toxicity Phenocopies

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An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment

An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment

Published on: September 13, 2016

Area of Science:

Ophthalmology
Toxicology
Pharmacology

Background:

The retina is susceptible to toxic effects from systemic, intravitreal, and topical medications.
The blood-ocular barrier does not fully protect the retina from drug-induced damage.

Purpose of the Study:

To categorize and describe the various forms of drug-induced retinal toxicity.
To highlight the vulnerability of the retina to medications.

Main Methods:

Review of literature on drug-induced retinal toxicity.
Classification of observed retinal damage based on affected structures and clinical presentation.

Main Results:

Drug-induced retinal toxicities manifest in diverse ways, including damage to the retinal pigment epithelium (RPE) and photoreceptors.
Other effects include vascular damage, optic nerve compromise, cystoid macular edema, crystalline retinopathy, and uveitis.
Changes in color vision and electroretinography (ERG) are also noted consequences.

Conclusions:

Drug-induced retinal toxicity is a significant clinical concern with a broad spectrum of ocular manifestations.
Understanding these diverse toxicities is crucial for diagnosis and management in patients using various medications.