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Updated: Jan 31, 2026

Transvaginal Mesh Insertion in the Ovine Model
Published on: July 27, 2017
Morbidity of a Single Incision Transvaginal Mesh to Correct Apical Prolapse
Stephen T Jeffery1, Brita S Kortz2, Dakalo Muavha1
1Department of Obstetrics and Gynecology, Groote Schuur Hospital, University of Cape Town, South Africa (Drs. Jeffery, Muavha, and Ras).
Study Objective:
To determine complications and related reintervention rates associated with use of the Uphold Vaginal Support System (Boston Scientific, Boston, MA) for symptomatic vaginal apical prolapse.
Design:
A multicenter retrospective study.
Setting:
Two teaching hospitals.
Patients:
Fifty-nine women with symptomatic vaginal apical prolapse.
Intervention:
Vaginal apical prolapse surgery using the Uphold Mesh Kit system with or without other concomitant procedures.
Measurements And Main Results:
A chart review was performed, including the following parameters: perioperative and postoperative complications, repeat surgery, and recurrence rate. A total of 59 patients met the criteria for inclusion in the study. Bladder perforation occurred perioperatively in 1 patient. Postoperative voiding difficulties were observed in 16 patients (27.1%), including 9 women (15.2%) who left the hospital with an indwelling catheter in place. There were 5 cases (8.5%) of transient groin pain, all of which resolved spontaneously. One patient developed a vaginal hematoma. Nine women (15%) required reoperation, including 4 (6.7%) because of recurrent prolapse and 1 (2%) for pelvic pain considered related to the mesh. Three patients (5%) required release of a midurethral sling (MUS) that had been placed concomitantly with the Uphold system. Two patients (3%) required a MUS for de novo stress incontinence.
Conclusion:
Use of the Uphold Vaginal Support System for symptomatic vaginal apical prolapse was associated with a significant risk of obstructed micturition. In our study population, 15% required repeat surgery, mainly for recurrent pelvic organ prolapse and de novo stress urinary incontinence. No surgical-related complication resulted in long-term morbidity.
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