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Rare T-Cell Subtypes.

C van der Weyden1, C McCormack2,3,4, S Lade4,5

  • 1Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Australia. carrie.vanderweyden@petermac.org.

Cancer Treatment and Research
|January 1, 2019
PubMed
Summary
This summary is machine-generated.

This chapter details rare T-cell lymphoma subtypes, refining diagnoses with new techniques. It summarizes current treatment approaches and management controversies for these uncommon conditions.

Keywords:
Acral CD8-positive T-cell lymphomaCD4-positive small/medium T-cell lymphoproliferative disorderCutaneous gamma-delta T-cell lymphomaEnteropathy-associated T-cell lymphomaMonomorphic epitheliotropic intestinal T-cell lymphomaPrimary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphomaPrimary cutaneous T-cell lymphomaSubcutaneous panniculitis-like T-cell lymphoma

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Area of Science:

  • Hematology
  • Oncology
  • Dermatology

Background:

  • Rare T-cell lymphomas present diagnostic challenges in clinical practice.
  • Advances in immunohistochemistry and molecular profiling are refining diagnostic categories.
  • Several distinct T-cell lymphoma subtypes require better elucidation.

Purpose of the Study:

  • To cover diagnostic and clinical features of common rare T-cell lymphoma subtypes.
  • To provide a summation of current thinking on optimal treatment approaches.
  • To highlight controversies in the management of these rare conditions.

Main Methods:

  • Review of diagnostic and clinical features.
  • Synthesis of current treatment strategies.
  • Identification of management controversies.

Main Results:

  • Refined diagnostic categories for rare T-cell lymphomas.
  • Detailed descriptions of subcutaneous panniculitis-like T-cell lymphoma, cutaneous gamma-delta T-cell lymphoma, enteropathy-associated T-cell lymphoma, monomorphic epitheliotropic intestinal T-cell lymphoma, primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma, CD4-positive small/medium T-cell lymphoproliferative disorder, and acral CD8-positive T-cell lymphoma.
  • Summary of current treatment considerations and controversies.

Conclusions:

  • Improved diagnostic techniques aid in classifying rare T-cell lymphomas.
  • Optimal treatment strategies are evolving due to limited clinical trial data.
  • Further research is needed to establish evidence-based management guidelines for these rare conditions.