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Tissue Transplantation01:24

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant III: Nursing Management01:16

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Robot-Assisted Kidney Transplantation
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Transplantation.

Jasmine Zain1

  • 1City of Hope National Medical Center, Duarte, CA, USA. jazain@coh.org.

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|January 1, 2019
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Summary
This summary is machine-generated.

Hematopoietic cell transplantation (HCT) plays a key role in treating mature T-cell lymphomas. Autologous HCT is recommended for early-stage disease, while allogeneic HCT offers long-term remission for relapsed or advanced T-cell lymphomas.

Keywords:
Allogeneic hematopoietic cell transplantationAutologous hematopoietic cell transplantationCutaneous T-cell lymphomaGraft-versus-lymphomaNK/T-cell lymphomaPeripheral T-cell lymphoma

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Area of Science:

  • Hematology
  • Oncology
  • Transplantation Immunology

Background:

  • Mature T-cell non-Hodgkin lymphomas (T-cell NHL) are diverse lymphoid malignancies.
  • Hematopoietic cell transplantation (HCT) is crucial for T-cell NHL management, but optimal strategies remain debated.
  • Classifications include systemic PTCL, cutaneous T-cell lymphomas (CTCL), and NK/T-cell lymphomas.

Purpose of the Study:

  • To outline the role of HCT in the treatment of T-cell lymphomas based on existing evidence.
  • To discuss the application of autologous and allogeneic HCT for different T-cell NHL subtypes.

Main Methods:

  • Review of retrospective and prospective trials on HCT for T-cell lymphomas.
  • Analysis of treatment outcomes based on transplant type and disease subtype.

Main Results:

  • Autologous HCT is recommended in first complete remission for systemic PTCL, offering long-term remission for relapsed disease but ineffective for refractory cases.
  • Allogeneic stem cell transplantation (AlloHCT) provides long-term remission for relapsed PTCL and advanced CTCL by leveraging the graft-versus-lymphoma effect.
  • Transplant for NK/T-cell lymphoma is primarily recommended for relapsed cases due to effective upfront treatments for limited stages.

Conclusions:

  • HCT is a vital therapeutic option for various T-cell lymphomas.
  • The choice between autologous and allogeneic HCT depends on the specific subtype, disease status (relapsed vs. refractory), and stage.
  • Further research is needed to refine HCT strategies for these rare and heterogeneous malignancies.