Related Experiment Video
Updated: Jan 31, 2026
08:03
Recording EEG in Freely Moving Neonatal Rats Using a Novel Method
Published on: May 29, 2017
13.9K
Tonic-clonic seizure detection using accelerometry-based wearable sensors: A prospective, video-EEG controlled study
Dongni Johansson1, Fredrik Ohlsson2, David Krýsl3
1Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Seizure
|January 6, 2019
Summary
This study shows that wearable accelerometry systems can accurately detect tonic-clonic seizures (TCSs), with algorithms achieving high sensitivity and low false positive rates for improved epilepsy management.
Area of Science:
- Neurology
- Biomedical Engineering
- Wearable Technology
Background:
- Epilepsy management relies on accurate seizure frequency assessment.
- Wearable accelerometry offers a potential solution for continuous, objective seizure monitoring.
Purpose of the Study:
- To evaluate an accelerometry-based wearable system for detecting tonic-clonic seizures (TCSs).
- To compare the accuracy of different seizure detection algorithms using distinct training and testing datasets.
Main Methods:
- Prospective video-electroencephalography (video-EEG) controlled study involving 75 epilepsy surgery candidates.
- Patients wore three-axis accelerometers on each wrist during video-EEG monitoring.
- Movement data was processed into a time-frequency feature space, and algorithms (KNN, RF, SVM) were trained and tested.
Main Results:
- Thirty-seven tonic-clonic seizures (TCSs) were analyzed across 11 patients.
- K-nearest-neighbors (KNN) achieved 100% sensitivity with 0.05 false positives per hour (FP/h).
- Random forest (RF) demonstrated 90% sensitivity with a low 0.01 FP/h.
Conclusions:
- The developed accelerometry system shows high accuracy for TCS detection.
- Low false positive rates support clinical utility for long-term seizure monitoring.
- Automated detection in free-living environments can improve seizure frequency ascertainment and management.
More Related Videos
Related Concept Videos
00:59Tonicity in Animals
123.8K
The tonicity of a solution determines if a cell gains or loses water in that solution. The tonicity depends on the permeability of the cell membrane for different solutes and the concentration of nonpenetrating solutes in the solution within and outside of the cell. If a semipermeable membrane hinders the passage of some solutes but allows water to follow its concentration gradient, water moves from the side with low osmolarity (i.e., less solute) to the side with higher osmolarity (i.e.,...
123.8K
01:16Tonicity in Animals
5.2K
Tonicity describes the amount of solute in a solution. The measure of the tonicity of a solution, or the total amount of solutes dissolved in a specific amount of solution, is called its osmolarity. Three terms—hypotonic, isotonic, and hypertonic—are used to relate the osmolarity of a cell to the osmolarity of the extracellular fluid that contains the cells. In a hypotonic solution, such as tap water, the extracellular fluid has a lower concentration of solutes than the fluid inside...
5.2K
00:53Tonicity in Plants
59.8K
Tonicity describes the capacity of a cell to lose or gain water. It depends on the quantity of solute that does not penetrate the membrane. Tonicity delimits the magnitude and direction of osmosis and results in three possible scenarios that alter the volume of a cell: hypertonicity, hypotonicity, and isotonicity. Due to differences in structure and physiology, tonicity of plant cells is different from that of animal cells in some scenarios.
59.8K
01:20Tonicity in Plants
32.7K
Plant cells maintain appropriate osmotic balance in extreme conditions. For instance, plants in dry environments store water in vacuoles, limit the opening of their stoma, and have thick, waxy cuticles to prevent unnecessary water loss. Some species of plants that live in salty environments store salt in their roots. As a result, water osmosis occurs in the root from the surrounding soil.
Tonicity
Tonicity describes the capacity of a cell to lose or gain water depending on the solute...
Tonicity
Tonicity describes the capacity of a cell to lose or gain water depending on the solute...
32.7K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
467
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
467
01:13Seizures: Classification
1.6K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.6K