NEOCORTICAL IMPACT ON THE AUDIOGENIC SEIZURE ACTIVITY DEVELOPMENT
M Barbakadze1, I Bilanishvili1, N Khizanishvili1
1I.Beritashvili Center of Experimental Biomedicine, Tbilisi; University Geomedi, Tbilisi; David Agmashenebeli University of Georgia, Tbilisi, Georgia.
Georgian Medical News
|January 9, 2019
Summary
Audiogenic seizures in Krushinsky-Molodkina rats were studied. Neocortical activation with strychnine increased seizure latency, suggesting a modulatory role for the thalamic reticular nucleus in audiogenic epilepsy.
Area of Science:
- Neuroscience
- Epilepsy Research
- Animal Models
Background:
- Audiogenic seizures are a genetically determined epilepsy model triggered by sound.
- The inferior colliculus and brainstem reticular nuclei are critical for these seizures.
- The role of diencephalic structures, like the thalamic reticular nucleus, is unclear.
Purpose of the Study:
- To investigate the modulatory effect of neocortical activation on audiogenic seizures.
- To explore the involvement of the thalamic reticular nucleus in seizure modulation.
Main Methods:
- Chronic experiments were conducted on eight Krushinsky-Molodkina (KM) strain rats.
- Bilateral neocortical activation was achieved using strychnine administration.
- Electrical activity was recorded from the neocortex and brainstem reticular formation.
Main Results:
- Strychnine-induced neocortical discharges increased the latency of wild runs.
- A pause between the first and second wild runs also increased in response to sound stimuli.
- These findings suggest a link between neocortical activity and seizure response.
Conclusions:
- Neocortical activation appears to modulate audiogenic seizures.
- Increased neuronal activity in the thalamic reticular nucleus may underlie this modulation.
- This study highlights potential therapeutic targets for audiogenic epilepsy.
More Related Videos
Related Concept Videos
01:19Impact of Groups on Groups
246
Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
246
01:13Seizures: Classification
1.6K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.6K
01:43Sustainable Development
15.1K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.1K
01:30Impact
495
Impact occurs when two bodies collide, leading to the application of impulsive forces between them. Analyzing impact mechanics involves considering two colliding particles moving along a line known as the line of impact, which passes through their centers and is perpendicular to the contact plane.
When particles with different initial velocities collide, they induce deformation by applying equal and opposite impulses. At the point of maximum deformation, the particles move together with...
When particles with different initial velocities collide, they induce deformation by applying equal and opposite impulses. At the point of maximum deformation, the particles move together with...
495
01:24Epilepsy and Seizures: Overview
1.3K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.3K
01:28Impact of Groups on Individuals
349
Groups play a fundamental role in shaping individual behavior, as they establish norms that guide interactions and decision-making. Social psychology examines how individuals conform to group expectations, often adjusting their attitudes and actions to align with group norms. These norms can be formal, such as workplace policies, or informal, such as unspoken social expectations within a fraternity.Conformity and Social InfluenceConformity arises when individuals modify their behaviors or...
349