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Updated: Jan 31, 2026

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
Published on: April 29, 2014
Impact of the Microenvironment on Tumour Budding in Colorectal Cancer
Laurent Mc Georges1, Laurine Verset1, Inti Zlobec2
1Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Abstract:
Tumour Budding (TB) is recognized as an adverse prognostic factor in colorectal cancer (CRC). TB is the detachment of isolated cancer cells or small clusters of such cells mainly at the invasion front. One question that arises is of the role of the tumour stroma regarding the permissiveness of the formation and progression of TB. In this review, we will examine potential factors affecting TB, in particular we will analyse the potential effect of inflammation, hypoxia, extracellular matrix and Cancer-Associated Fibroblasts (CAFs).
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