Related Experiment Video
Updated: Jan 31, 2026
06:24
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
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[Gender aspects in angioedema]
G Bindke1, K Schorling1, D Wieczorek1
1Klinik für Dermatologie, Allergologie und Venerologie, Comprehensive Allergy Center (CAC), Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
Summary
Gender significantly impacts bradykinin-mediated angioedema, particularly hereditary angioedema (HAE), with hormonal influences and specific localizations noted in women. This highlights the need for gender-specific HAE therapies and biomarkers.
Area of Science:
- Medical Science
- Immunology
- Genetics
Background:
- Angioedema is triggered by bradykinin or histamine.
- Gender-specific differences in angioedema are largely unknown.
- Biomarkers for angioedema monitoring and therapy are needed.
Purpose of the Study:
- To investigate gender-related differences in angioedema.
- To explore variations in triggers, clinical parameters, and therapy response.
- To identify gender-specific biomarkers for angioedema management.
Main Methods:
- Literature search in PubMed using keywords 'angioedema' and 'sex' or 'gender'.
- Screening of reviews, guidelines, and registration studies.
- Analysis of gender-specific data in angioedema types.
Main Results:
- Few gender differences in histamine-mediated angioedema.
- Women are more affected by bradykinin-mediated hereditary angioedema (HAE), especially with Factor XII mutation.
- Hormonal influences and gender-specific localization are documented in HAE; women comprise two-thirds of HAE trial participants.
Conclusions:
- Differentiating angioedema into estrogen-dependent, -sensitive, and -insensitive subtypes is proposed.
- Understanding hormonal effects can improve pathomechanism knowledge.
- Development of biomarkers for targeted, gender-specific HAE therapy is crucial for patient well-being.
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