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What is Gene Expression?

What is Gene Expression?

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Cell Specific Gene Expression

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

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Chromatin Position Affects Gene Expression

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Related Experiment Video

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Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

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Post-Weaning Social Isolation Disturbs Gene Expression in Rat Brain Structures.

E A Zubkov¹, Ya A Zorkina¹, E V Orshanskaya²

¹Department of Basic and Applied Neurobiology, V. P. Serbsky National medical Research Center of Psychiatry and Narcology, Ministry of Health of Russian Federation, Moscow, Russia.

Bulletin of Experimental Biology and Medicine

|January 11, 2019

Summary

Post-weaning social isolation in rats increased aggressiveness and cognitive deficits. Gene expression changes, particularly in the serotonergic system and prolyl endopeptidase, suggest involvement in these mental health disorders.

Keywords:

animal model brain structures gene expression post-weaning social isolation rats

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Area of Science:

Neuroscience
Molecular Biology
Behavioral Science

Background:

Post-weaning social isolation is a significant environmental stressor.
Social isolation in rodents is known to induce behavioral and neurochemical alterations.

Purpose of the Study:

To investigate the molecular mechanisms underlying behavioral changes induced by social isolation.
To identify candidate genes involved in the pathogenesis of isolation-induced mental disorders.

Main Methods:

Male Wistar rats were subjected to 10 weeks of social isolation.
Behavioral assessments included aggressiveness, sensorimotor reactivity, and cognitive function (acoustic startle response).
Gene expression analysis of key enzymes and transporters in various brain regions was performed using mRNA levels.

Main Results:

Social isolation led to increased aggressiveness, sensorimotor reactivity, and cognitive deficits.
Elevated expression of prolyl endopeptidase (EC 3.4.21.26) in the frontal cortex was observed.
Increased serotonin transporter gene mRNA levels were found in the striatum and hypothalamus.

Conclusions:

The serotonergic system plays a role in mental disorders induced by social isolation.
The gene encoding prolyl endopeptidase is a potential candidate gene in the pathogenesis of isolation-induced mental disorders.