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Multiple Roles, Multiple Adaptors: Dynein During Cell Cycle.

Devashish Dwivedi1, Mahak Sharma2

  • 1Department of Biological Sciences, Indian Institute of Science Education and Research (IISER), Mohali, Punjab, India. devashishdwivedi@iisermohali.ac.in.

Advances in Experimental Medicine and Biology
|January 15, 2019
PubMed
Summary
This summary is machine-generated.

Dynein, a crucial motor protein complex, drives essential cellular functions like transport and division. This review details dynein

Keywords:
AdaptorCell cycleDynactinDyneinHook2KinetochoreMitotic spindle

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Dynein is a large, complex motor protein essential for eukaryotic cell functions.
  • Its roles include ciliary beating, intracellular transport, and cell division.
  • Understanding dynein's mechanism is challenging due to its size and complexity.

Purpose of the Study:

  • To provide an overview of dynein structure and function.
  • To focus on dynein's roles throughout the cell cycle.
  • To review the function of dynactin and adaptor proteins in dynein regulation.

Main Methods:

  • Review of existing literature on dynein structure, function, and regulation.
  • Analysis of studies on dynein localization and activity during the cell cycle.
  • Examination of the roles of dynactin and adaptor proteins.

Main Results:

  • Dynein participates in various cellular processes, including retrograde transport via association with dynactin and adaptors.
  • Dynein localizes to multiple sites in mitotic cells, including the nuclear envelope, kinetochores, and spindle.
  • Dynein regulates key cell cycle events such as chromosome segregation and spindle positioning.

Conclusions:

  • Dynein is a critical regulator of cell cycle progression.
  • Dynactin and adaptor proteins are essential for controlling dynein's recruitment and activity.
  • Further research into dynein mechanisms will enhance understanding of cell biology.