Related Experiment Video
Updated: Jan 30, 2026
06:23
Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence
Published on: January 17, 2025
1.2K
Changes in the Nuclear Envelope in Laminopathies.
Subarna Dutta1,2, Maitree Bhattacharyya2, Kaushik Sengupta3
1Biophysics & Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, West Bengal, India.
Advances in Experimental Medicine and Biology
|January 15, 2019
Summary
Mutations in lamins, proteins crucial for nuclear stability, disrupt nuclear homeostasis. This disruption leads to a range of diseases known as laminopathies, affecting cellular functions.
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- The nucleus, a double-membrane organelle, regulates vital cellular processes including DNA replication and transcription.
- Nuclear homeostasis relies on the integrity of the nuclear membrane and associated proteins.
- Lamins, located beneath the inner nuclear membrane, are essential for maintaining nuclear stability.
Purpose of the Study:
- To review the disruption of nuclear homeostasis caused by mutations in lamin A/C.
- To explore the diverse diseases, termed laminopathies, resulting from these mutations.
Main Methods:
- Literature review focusing on lamin A/C mutations and their consequences.
- Analysis of the role of lamins in nuclear structure and function.
- Compilation of information on diseases associated with laminopathies.
Main Results:
- Lamin A/C mutations significantly disrupt nuclear homeostasis.
- These mutations lead to a wide spectrum of diseases, collectively known as laminopathies.
- The integrity of the nuclear membrane and lamins is critical for normal cellular function.
Conclusions:
- Lamin A/C mutations are a primary cause of laminopathies.
- Understanding lamin function is key to addressing these diseases.
- Maintaining nuclear homeostasis is vital for overall cell health.
Related Concept Videos
01:18Outer Layers of the Cell Envelope
1.1K
The outermost layers of prokaryotic cells play a critical role in their survival, virulence, and interaction with the environment. These layers, often composed of polysaccharides, polypeptides, or proteins, form protective and adhesive structures that vary in organization and function.Capsules and Slime LayersCapsules are highly organized, tightly bound layers that firmly attach to the bacterial cell wall. Capsules are usually made of polysaccharides, though some are made of polypeptides. These...
1.1K
03:18Nuclear Stability
23.2K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
To hold positively charged protons together...
23.2K
02:45Nuclear Fusion
33.8K
The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
33.8K
01:29Non-nuclear Inheritance
23.2K
Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm—such as chloroplasts and mitochondria—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
23.2K
02:31Nuclear Export of mRNA
8.8K
Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
8.8K
03:20Nuclear Transmutation
20.7K
Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
20.7K