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Muscle Fiber Splitting Is a Physiological Response to Extreme Loading in Animals
Kevin A Murach1,2, Cory M Dungan1,2, Charlotte A Peterson1,2
1Center for Muscle Biology.
Abstract:
Skeletal muscle fiber branching and splitting typically is associated with damage and regeneration and is considered pathological when observed during loading-induced hypertrophy. We hypothesize that fiber splitting is a nonpathological component of extreme loading and hypertrophy, which is primarily supported by evidence in animals, and propose that the mechanisms and consequences of fiber splitting deserve further exploration.
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