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Anogenital Ulcers: An Unusual Manifestation of Invasive Aspergillosis

Pablo Vargas1, Fernando Valenzuela1, Viera Kaplan1

  • 1Department of Dermatology, Faculty of Medicine, University of Chile, Santiago, Chile.

Case Reports in Dermatological Medicine
|January 22, 2019
PubMed

Insights

Invasive aspergillosis, a serious opportunistic fungal infection, can manifest as skin ulcers. This case highlights a severe presentation in an elderly woman, despite aggressive antifungal treatment.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Aspergillus species are common fungi, typically causing disease only in immunocompromised individuals.
  • Opportunistic fungal infections are increasing, posing significant morbidity and mortality risks.
  • Invasive aspergillosis can originate from skin injury, tissue extension, or hematogenous spread, commonly from pulmonary infections.

Observation:

  • This report details a case of invasive aspergillosis in an elderly woman.
  • The infection presented with severe anogenital and skin ulcers.
  • The patient had an unfavorable outcome despite intensive antifungal therapy.

Findings:

  • Invasive aspergillosis can manifest with extensive cutaneous and mucocutaneous lesions.
  • Elderly patients may be at higher risk for severe presentations.
  • Aggressive antifungal treatment may not always ensure a favorable outcome in severe invasive aspergillosis.

Implications:

  • This case underscores the potential for severe, disseminated disease in invasive aspergillosis, even in the absence of typical risk factors.
  • Early recognition and aggressive management are crucial, but outcomes can still be poor.
  • Further research into risk factors and treatment strategies for invasive aspergillosis in vulnerable populations is warranted.

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