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Related Experiment Videos

Foam-covered mammary implants.

K G Brand1

  • 1University of Minnesota Medical School, Minneapolis.

Clinics in Plastic Surgery
|October 1, 1988
PubMed
Summary
This summary is machine-generated.

Polyurethane-coated implants effectively prevent implant contracture and fibrosis. These coated implants also show reduced tumorigenicity in mice and do not appear to increase inflammation compared to uncoated implants.

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Area of Science:

  • Biomaterials Science
  • Medical Device Engineering
  • Surgical Innovation

Background:

  • Implantable devices often elicit foreign body responses, including fibrosis and capsule formation.
  • Silicone implants are widely used but can lead to complications like contracture.
  • The development of improved implant coatings is crucial for enhancing patient outcomes.

Purpose of the Study:

  • To evaluate the efficacy of polyurethane coating in preventing adverse tissue reactions around silicone implants.
  • To assess the inflammatory and tumorigenic potential of polyurethane-coated versus uncoated implants.
  • To determine the long-term biocompatibility of polyurethane-coated implants.

Main Methods:

  • Comparative analysis of polyurethane-coated and uncoated silicone implants in an experimental setting.

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  • Histological examination to assess fibrosis, capsule formation, and inflammation.
  • Tumorigenicity studies in a murine model.
  • Assessment of implant surface integrity and coverage.

    • Main Results:

    • Polyurethane coating significantly inhibited longitudinal fibrosis, circumferential capsule formation, and implant contracture.
    • No evidence suggests polyurethane-coated implants promote septic inflammation more than uncoated implants.
    • Polyurethane-coated implants demonstrated reduced tumorigenicity in mice compared to uncoated implants.
    • Effective and complete coverage of the silicone surface by the polyurethane coating was critical for preventing fibrosis.

    Conclusions:

    • Polyurethane coating is a viable strategy to mitigate fibrosis and contracture associated with silicone implants.
    • Polyurethane-coated implants exhibit a favorable safety profile regarding inflammation and tumorigenicity.
    • The findings support the use of polyurethane-coated implants for improved biocompatibility and reduced complication rates.