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Poly(ester amide) particles for controlled delivery of celecoxib
Ian J Villamagna1,2, Trent N Gordon3, Mark B Hurtig4
1School of Biomedical Engineering, The University of Western Ontario, London, Ontario N6A 5B9, Canada.
Journal of Biomedical Materials Research. Part A
|January 31, 2019
Summary
Researchers developed novel poly(ester amide) particles for targeted osteoarthritis drug delivery. These particles, loaded with celecoxib, showed controlled release and good biocompatibility in animal models, offering a promising alternative to systemic treatments.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Osteoarthritis Therapeutics
Background:
- Systemic drug administration for osteoarthritis can cause side effects.
- Intra-articular drug delivery offers a targeted alternative.
- Poly(ester amide)s (PEAs) are promising for intra-articular delivery vehicles, but limited structural variations have been explored.
Purpose of the Study:
- To prepare and characterize two distinct PEA particles (PBSe and POSe) for drug delivery.
- To encapsulate celecoxib (CXB) into these PEA particles.
- To evaluate the properties, drug release, toxicity, and in vivo host response of the PEA-CXB particles.
Main Methods:
- Synthesis and characterization of PBSe and POSe particles from l-phenylalanine, sebacic acid, and diols.
- Encapsulation of celecoxib (CXB) into the PEA particles.
- In vitro drug release studies, cytotoxicity assays (ATDC5, C2C12 cells), and in vivo intra-articular injection in an ovine model.
Main Results:
- PBSe and POSe particles exhibited different thermal and mechanical properties, influenced by CXB encapsulation.
- PBSe-CXB particles demonstrated slower in vitro celecoxib release compared to POSe-CXB.
- Particles showed low intrinsic toxicity, but PBSe-CXB exhibited concentration-dependent toxicity; no adverse effects were observed in the ovine model, with particles diffusing into surrounding tissues.
Conclusions:
- Structural modifications of PEA particles significantly impact their properties and drug release kinetics.
- PEA particles show potential as safe and effective intra-articular drug delivery vehicles for osteoarthritis.
- Further development and structural tuning of PEAs can optimize drug delivery for joint diseases.
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