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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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One of the distinctive characteristics of circular shafts is their ability to maintain their cross-sectional integrity under torsion. In other words, each cross-section continues to exist as a flat, unaltered entity, simply rotating like a solid, rigid slab. To understand the distribution of shearing stress within such a shaft, consider a cylindrical section inside this circular shaft. This section has a length of L and a radius of R, with one end fixed. The radius of the cylindrical section is...
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Use of Alu Element Containing Minigenes to Analyze Circular RNAs
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CircFunBase: a database for functional circular RNAs.

Xianwen Meng1,2, Dahui Hu1, Peijing Zhang1

  • 1Department of Bioinformatics, the State Key Laboratory of Plant Physiology and Biochemistry, Institute of Plant Science, College of Life Sciences, Zhejiang University, Hangzhou, China.

Database : the Journal of Biological Databases and Curation
|February 5, 2019
PubMed
Summary
This summary is machine-generated.

CircFunBase is a new database offering over 7000 functional circular RNA (circRNA) entries. This resource aids researchers by detailing circRNA functions and interactions, advancing the study of these important molecules.

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Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • Circular RNAs (circRNAs) are prevalent in eukaryotes and crucial for various biological processes.
  • A significant gap exists in comprehensive, functionally annotated circRNA databases.
  • Understanding circRNA functions is essential for advancing biological research.

Purpose of the Study:

  • To introduce CircFunBase, a novel web-accessible database for functional circRNAs.
  • To provide a high-quality resource of experimentally validated and computationally predicted circRNA functions.
  • To facilitate circRNA research by consolidating functional information and interaction networks.

Main Methods:

  • Manual curation of over 7000 functional circRNA entries.
  • Integration of data primarily from Homo sapiens and Mus musculus.
  • Development of visualized circRNA-miRNA interaction networks and a genome browser.

Main Results:

  • CircFunBase currently houses >7000 manually curated functional circRNA entries.
  • The database includes visualized circRNA-miRNA interaction networks.
  • A genome browser is available for visualizing circRNA genomic context.

Conclusions:

  • CircFunBase serves as a valuable biological information platform for circRNAs.
  • The database aims to bridge the gap between circRNAs and their known functions.
  • CircFunBase will significantly contribute to the advancement of circRNA research.