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Updated: Nov 9, 2025

Identification of Circular RNAs using RNA Sequencing
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Identification of Circular RNAs using RNA Sequencing

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Database Resources for Functional Circular RNAs.

Dahui Hu1, Peijing Zhang1, Ming Chen2

  • 1Department of Bioinformatics, The State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, China.

Methods in Molecular Biology (Clifton, N.J.)
|April 9, 2021
PubMed
Summary
This summary is machine-generated.

CircFunBase is a database offering functional insights into circular RNAs (circRNAs). It aids researchers in understanding circRNA roles through validated and predicted functions, visualized interactions, and genome context.

Keywords:
CircFunBaseCircRNACircRNA functionCircRNA interactionDatabase

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Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • Circular RNA (circRNA) molecules are crucial regulators in various biological pathways.
  • Understanding the functions of circRNAs is essential for advancing biological research.
  • A centralized, annotated database is needed to consolidate circRNA functional information.

Purpose of the Study:

  • To introduce CircFunBase, a web-accessible database for functional circRNA research.
  • To provide a high-quality resource of experimentally validated and computationally predicted circRNA functions.
  • To facilitate the exploration of circRNA-miRNA interactions and genomic context.

Main Methods:

  • Development of a web-accessible database (CircFunBase).
  • Integration of experimentally validated and computationally predicted circRNA functions.
  • Implementation of visualized circRNA-miRNA interaction networks and a genome browser.

Main Results:

  • CircFunBase offers a comprehensive repository of functional circRNA data.
  • The database provides tools for visualizing circRNA-miRNA networks.
  • A genome browser enables visualization of circRNA genomic context.

Conclusions:

  • CircFunBase serves as a valuable resource for researchers studying circRNA functions.
  • The database enhances understanding of circRNA roles in biological processes.
  • CircFunBase supports the exploration of circRNA-related biological questions.